69 articles - From Friday May 27 2022 to Friday Jun 03 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
Clinical trial: a single-centre, randomised, controlled trial of tradipitant on satiation, gastric functions, and serum drug levels in healthy volunteers. Tradipitant, 85 |
Home-based, tunnelled peritoneal drainage system as an alternative treatment option for patients with refractory ascites. After PPSM, mortality was lower in the PeCa group (HR:0.40; p = 0.03), whereas the incidence of SBP and hyponatraemia was comparable (p = 0.80 and p = 0.28) and AKI was more frequent in those with a PeCa (p = 0.08). The implant of PeCa allows home-based therapy of RA in patients with liver cirrhosis and contraindication for TIPS. However, the risk for complications such as AKI or hyponatraemia has to be considered and prospective studies are needed. |
Strongly increased risk of gastric and duodenal ulcers among new users of low-dose aspirin: Results from two large cohorts with new-user design. This study shows that low-dose aspirin is an independent risk factor for both gastric and duodenal ulcers. The associations were not significant or weak in the prevalent-user design and strong and statistically significant in the new-user design in both cohorts. Thus, it is important to weigh risks against benefits when low-dose aspirin treatment shall be initiated and to monitor adverse gastrointestinal symptoms after the start of low-dose aspirin therapy. |
The disease severity index for inflammatory bowel disease is associated with psychological symptoms, quality of life and predicts a more complicated disease course. The DSI is associated with psychological distress, impaired QoL and predicts a more complicated disease course in patients with IBD. |
| Clin Gastroenterol Hepatol |
Biopsy of non-tumor sites after biopsy of a colorectal cancer is not associated with metachronous cancers: a case-control study. Metachronous cancers are not significantly associated with biopsy of non-tumor sites after biopsy of the primary cancer. Although the sample size does not allow definite exclusion of any association, these findings do not support iatrogenic tumor seeding as a common risk factor for metachronous CRC. |
Endoscopic surveillance for premalignant esophageal lesions: A community-based multicenter, prospective cohort study. In a country with a high incidence of ESCC, patients with mild-moderate dysplasia showed an overall risk of advanced neoplasia progression of 1.04% per year. Patients with mild-moderate dysplasia would be recommended for endoscopic surveillance during the first 2-3 years. |
Gallstone Disease and its Association with Nonalcoholic Fatty Liver Disease, All-Cause and Cause-Specific Mortality. Gallstone disease is an independent risk factor for NAFLD, but gallstone disease is not associated with all-cause mortality in individuals with NAFLD. Screening for gallstone disease in individuals at risk for developing NAFLD may help with risk stratification for all-cause mortality related to gallstone disease. |
Poor diagnostic efficacy of noninvasive tests for advanced fibrosis in obese or younger than 60 diabetic NAFLD patients. The worst performance was observed in younger patients with T2DM for al NITs including FIB-4 (AUROC 0.63-0.66). results CONCLUSION: FIB-4 had higher diagnostic efficacy for F3-4 than NFS or HFS, but this varied greatly by age, BMI and T2DM, with better performance in older, nonobese, and nondiabetic patients. However, al NITs including FIB-4 had unacceptably poor performance in young or obese diabetic patients. |
Superior effectiveness of tofacitinib compared to vedolizumab in anti-TNF experienced ulcerative colitis patients: a nationwide Dutch Registry study. Tofacitinib was associated with superior effectiveness outcomes compared to vedolizumab in anti-TNF experienced UC patients along with comparable safety outcomes. |
Understanding Prognosis: Discrepancy in Prognosis Estimates between Patients with Cirrhosis and their Hepatologists. Patients with cirrhosis are more optimistic and less accurate in their predictions of survival compared to hepatologists, though they are more realistic about their transplant candidacy. Aligning patient and provider expectations may increase the likelihood that patients receive value-concordant care. |
Unplanned healthcare utilization and safety of biologic therapy in Hispanic vs. non-Hispanic patients with IBD: A CA-IBD Cohort Study. In a multicenter, propensity score-matched cohort of biologic-treated patients with IBD, Hispanic patients experienced higher rates of hospitalization, surgery, and serious infections. Future studies are needed to investigate the biological, social, and environmental drivers of these differences. |
Utility of Anorectal Testing to Predict Outcomes with Pelvic Floor Physical Therapy in Chronic Constipation: Pragmatic Trial. Using ARM to evaluate squeeze profiles, rather than dyssynergia, appears useful to screen patients with chronic constipation for up-front pelvic floor physical therapy based on likelihood of response. BET appears non-informative as a single screening test.(ClinicalTrials.gov NCT04159350). |
| Endoscopy |
Diagnostic endoscopic submucosal dissection for colorectal lesions with suspected deep invasion. ESD is feasible and safe for colorectal lesions with FDIP = 15 mm. It cured 26.2% of patients and could be a valid option for 30.2% of additional patients with low-risk T1 cancers, especially for fragile patients with comorbidities. |
Performance measures for the SACRED team-centered approach to advanced gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative. Quality indicators to guide endoscopists in the growing field of advanced endoscopy are also underway. We propose that equal attention is given to developing the entire advanced endoscopy team and not the individual endoscopist alone. We suggest that the practice of teams intending to deliver high quality advanced endoscopy is underpinned by six crucial principles concerning: selection, acceptance, complications, reconnaissance, envelopment, and documentation (SACRED). |
The Toronto Upper Gastrointestinal Cleaning Score (TUGCS): A Prospective Validation Study. The TUGCS has strong evidence of validity in the clinical setting. The international group of assessors, broad variety of EGD indications, and minimal assessor training improves generalizability and potential for dissemination. |
| Gastroenterology |
Age-stratified prevalence and predictors of neoplasia among US adults undergoing screening colonoscopy in a national endoscopy registry. In a large US endoscopy registry, the prevalence of advanced neoplasia in 45-49 year-olds was substantial and supports beginning screening at age 45 years. White individuals had higher risk of advanced neoplasia than Black, Hispanic, and Asian individuals across the age spectrum. These findings may inform adenoma detection benchmarks and risk-based screening strategies. |
Association between Metabolic Syndrome and the Risk of Colorectal Cancer Diagnosed before 50 years According to Tumor Location. MetS and obesity are positively associated with CRC before age 50 with a similar magnitude of association as people diagnosed after age 50. Thus, people younger than age 50 with metabolic syndrome require effective preventive interventions to help reduce CRC risk. |
Computer-Aided Detection Improves Adenomas per Colonoscopy for Screening and Surveillance Colonoscopy: A Randomized Trial. For experienced endoscopists performing screening and surveillance colonoscopies in the US, the CADe device statistically improved overall adenoma detection (APC) without a concomitant increase in resection of non-neoplastic lesions (THR). |
Mediterranean-like dietary pattern associations with gut microbiome composition and sub-clinical gastrointestinal inflammation. Overall, these results indicated that Mediterranean-like dietary patterns are associated with microbiome and lower intestinal inflammation. This study will help guiding future dietary strategies that affect microbial composition and host gut inflammation to prevent diseases. |
Neutralizing anti-GM-CSF autoantibodies recognize posttranslational glycosylations on GM-CSF years prior to diagnosis and predict complicated Crohn's Disease. Anti-GMAb predict the diagnosis of complicated CD long before the diagnosis of disease, recognize uniquely glycosylated epitopes, and impair myeloid cell and ILC balance associated with altered intestinal immune homeostasis. |
Risk of cancer in inflammatory bowel diseases: umbrella review and re-analysis of meta-analyses. Associations between IBD and different types of malignancy showed varying levels of evidence and magnitude of risk. Further primary research investigating the impact of a consistent set of risk factors that are known to affect cancer risk is warranted. |
| Gastrointest Endosc |
Comparison of Cold Snare and Hot Snare Polypectomy for the Resection of Sporadic Non-Ampullary Duodenal Adenomas. HSP led to more delayed complications compared to CSP while no significant differences on outcomes were noted, suggesting that CSP is equally effective and potentially safer for the removal of duodenal adenomas. |
EUS-directed transgastric interventions in Roux-En-Y Gastric Bypass anatomy: a multicenter experience. EDGI is effective and safe for the diagnosis and management of pancreatobiliary and foregut disorders in RYGB patients. It is associated with high rates of technical success and low rates of severe AEs. LAMS migration is the most common AE with evidence that anchoring can be protective against its occurrence. Persistent fistulas may occur, but endoscopic closure seems effective. |
IMPROVING DIAGNOSTIC ACCURACY AND APPROPRIATE INDICATIONS FOR SURGERY IN PANCREATIC CYSTIC NEOPLASMS: THE ROLE OF ENDOSCOPIC ULTRASOUND. The overall risk of unnecessary immediate surgery for PCN is about 22% in a high-volume referral center. EUS with cytologic sampling is a useful procedure in the diagnostic management of PCNs, improving their diagnostic accuracy. |
| Gut |
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer. Loss of PI3K-C2 |
Phase II trial of weekly erlotinib dosing to reduce duodenal polyp burden associated with familial adenomatous polyposis. In this single-arm, multi-centre trial of participants with FAP, erlotinib one time per week resulted in markedly lower duodenal polyp burden, and modestly reduced lower GI polyp burden, after 6 months of intervention. While AEs were still reported by nearly three-quarters of al participants, these events were generally lower grade and well-tolerated. These findings support further investigation of erlotinib as an effective, acceptable cancer preventive agent for FAP-associated GI polyposis. |
| Hepatology |
Change in serial liver stiffness measurement by magnetic resonance elastography and outcomes in non-alcoholic fatty liver disease. Noninvasive monitoring of LSM by conventional MRE is a promising method of longitudinal NAFLD monitoring and risk estimation of liver-related outcomes in NAFLD. |
| Inflamm Bowel Dis |
Early Biological Therapy in Operated Crohn's Disease Patients Is Associated With a Lower Rate of Endoscopic Recurrence and Improved Long-term Outcomes: A Single-center Experience. Operated CD patients treated early with biologics experience decreased rates of endoscopic recurrence and improved long-term outcomes. |
Inflammatory Bowel Disease and Long-term Risk of Cancer: A Prospective Cohort Study Among Half a Million Adults in UK Biobank. Compared with non-IBD, IBD may be associated with an increased risk of overall cancer and cancer-specific mortality, particularly digestive cancers, nonmelanoma and male genital cancers. |
Long-term Risk of Herpes Zoster Infection in Patients With Ulcerative Colitis Receiving Tofacitinib. Most HZ events were mild/moderate. Herpes zoster IRs remained stable over 7.8 years of exposure. Older age, lower weight, geographic region, and prior TNFi failure were associated with increased HZ risk. NCT00787202;NCT01465763;NCT01458951;NCT01458574;NCT01470612;NCT03281304. |
| J Crohns Colitis |
Combining pentoxifylline with vedolizumab for Crohn's disease: results of a randomized, placebo-controlled pilot study. VDZ/PTX did not provide benefit over VDZ monotherapy in clinical or endoscopic remission but appeared to improve clinical response and was safe. These data should inform a fully powered study. |
Intestinal ultrasound early on in treatment follow-up predicts endoscopic response to anti-TNFa treatment in Crohn's Disease. Reduction in BWT, already after 4-8 weeks of follow-up, predicted endoscopic response and remission. CEUS parameters were of limited value. Furthermore, we have provided accurate cut-offs for BWT reflecting endoscopic response and remission at different time points. |
| J Hepatol |
Hepatitis D virus-induced interferon response and administered interferons control cell division-mediated virus spread. Both HDV-induced IFN response and exogenous IFN treatment suppress cell division-mediated HDV spread, presumably through acceleration of HDV RNA decay. Our findings demonstrate a novel mode-of-action of IFN, explain the more pronounced effect of IFN therapy in patients with lower HDV serum RNA levels, and provide insights for the development of combination therapies. |
Identification of a distinct NK-like hepatic T-cell population activated by NKG2C in a TCR-independent manner. In summary, the current study found a distinct CD56 hi CD161 - CD8 + T-cell population characterized by NK-like activation by TCR-independent NKG2C ligation. Further studies are required to elucidate the roles of liver sinusoidal CD56 hi CD161 - CD8 + T cells in immune responses to microbial pathogens or liver immunopathology. |
Impact of HBsAg seroclearance on late recurrence of hepatitis B virus-related hepatocellular carcinoma after surgical resection. HBsAg seroclearance is associated with a lower risk of late recurrence of HBV-related HCC among Korean patients treated with curative liver resection. |
Influence of hepatitis C viral parameters on pregnancy complications and risk of mother-to-child transmission. We evaluated the effect that hepatitis C has on pregnancy outcomes as well as the rate of hepatitis C transmission to infants in a large database with linked mother-infant records. We found that active hepatitis C during pregnancy increased the risk of pregnancy complications. We also identified very low rates of testing of infants born to mothers with hepatitis C, but found higher rates of hepatitis C transmission to infants in mothers with higher virus levels. |
Mechanisms of CD8+ T cell failure in chronic hepatitis E virus infection. Chronic HEV infection is associated with HEV-specific CD8+ T cell exhaustion, indicating that T cell exhaustion driven by persisting antigen recognition also occurs in severely immunosuppressed hosts. Functional reinvigoration of virus-specific T cells is at least partially possible when antigen is cleared. In a minority of patients, viral escape also contributes to HEV-specific CD8+ T cell failure and thus needs to be taken into account in personalized immunotherapeutic approaches. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
Diagnostic and therapeutic approach to persistent abdominal pain beyond irritable bowel syndrome. Persistent abdominal pain (PAP) is a challenging condition to diagnose and treat. Many patients undergo repeated diagnostic testing and treatment, including surgery, without achieving symptom relief. Increasing physician awareness of the various causes of PAP, especially of rare diseases that are less well known, may improve patient outcomes. |
| Clin Gastroenterol Hepatol |
| Gut |
Organoids in gastrointestinal diseases: from experimental models to clinical translation. Novel platforms such as organ-on-a-chip, engineered biomimetic systems including engineered organoids, micromanufacturing, bioprinting and enhanced rigour and reproducibility will open improved avenues for tissue engineering, as well as regenerative and personalised medicine. This review will highlight some of the established methods and also some exciting novel perspectives on organoids in the fields of gastroenterology. At present, this field is poised to move forward and impact many currently intractable GI diseases in the form of novel diagnostics and therapeutics. |
| Hepatology |
Letters to the editors and authors’ replies
| Clin Gastroenterol Hepatol |
| J Hepatol |
| Neurogastroenterol Motil |
all remaining publications eg case reports, images of the month, etc…
| Am J Gastroenterol |
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gut |
| Inflamm Bowel Dis |